Profiling Changes in Receptor Tyrosine Kinase Phosphorylation using Antibody Arrays

013 Video 1 Receptor tyrosine kinases

SOLVED: The activity of a kinase called Src is regulated by phosphorylation. The kinase is inactivated by a C-terminal tyrosine residue (Tyr527) and is activated by interaction with an activated RTK which causes it to autophosphorylate a different tyrosine residue (Tyr416). Full activation of Src requires removal of one phosphate group and binding to an activated RTK. Based on this information, which statement about the activity of Src kinase is correct? Choose one:a) The kinase is active only w