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Let’s talk about MCAS — Mast Cell Activation Syndrome. The tests we have? Honestly… not that helpful. Most have low sensitivity — meaning they can miss the diagnosis even when it’s really there. Serum tryptase? Often normal in MCAS. Urine prostaglandins, leukotrienes? Only elevated if you test right after a flare and the sample is handled perfectly. Real-world sensitivity? Likely under 50%. Here’s the key: one of the diagnostic criteria for MCAS is improvement with therapy. So if your symptoms i
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🤯This is what a mast cell activation syndrome (MCAS) flare looks like for me. I’ve been in one for the past two days, and honestly… it came out of nowhere. It could be because I exercised at Pilates. It could be delayed fallout from my immunoglobulin infusion a couple of weeks ago that already triggered a flare and then calmed down for a few days. Or it could just be my body doing what MCAS bodies sometimes do — flaring without a clear reason. And it is miserable.😩 🌟When my mast cells flare,
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