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Transdermal Patch Application
I almost always recommend transdermal estrogen over oral estrogen because it’s the safest and most physiologic option for women in midlife. When estrogen goes through the skin, it bypasses the liver—meaning it doesn’t spike clotting factors, doesn’t increase stroke risk, and doesn’t elevate inflammatory markers like CRP the way oral estrogen can. Transdermal keeps things steady: smoother symptom relief, better metabolic stability, and a cleaner cardiovascular profile. But, here’s the nuance, if
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I almost always recommend transdermal estrogen over oral estrogen because it’s the safest and most physiologic option for women in midlife. When estrogen goes through the skin, it bypasses the liver—meaning it doesn’t spike clotting factors, doesn’t increase stroke risk, and doesn’t elevate inflammatory markers like CRP the way oral estrogen can. Transdermal keeps things steady: smoother symptom relief, better metabolic stability, and a cleaner cardiovascular profile. But, here’s the nuance, if
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