Adiponectin plays a key role in glucose and fat metabolism, both crucial in diabetes prevention. According to our data, 66% of individuals are genetically predisposed to lower adiponectin levels, which can lead to challenges in insulin management. Fortunately, lifestyle interventions, including regular exercise and omega-3-rich diets, can support healthier adiponectin levels and contribute to effective diabetes management. Understanding this genetic marker provides a targeted path for those with