Video: A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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Bone loss is not “aging.” It’s signaling failure. Bone remodeling is a living biochemical negotiation between: Osteoblasts (builders) Osteoclasts (demolition) When demolition wins → osteoporosis, RA bone erosion, fragility fractures. 🔑 The Master Switch RANK / RANKL / OPG RANKL = green light for osteoclast creation RANK = receptor on osteoclast precursors OPG = decoy brake that blocks destruction Bone loss begins when RANKL > OPG. 🔥 Amplifiers That Push the System Into Collapse PTH (from low c
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