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YouTubeVJHemOnc – Video Journal of Hematology & HemOnc
The mechanism of action and potential of EB2023, an OXPHOS inhibitor, in acute myeloid leukemia
Matthew Villaume, MD, PhD, Vanderbilt University Medical Center, Nashville, TN, provides insight into EB2023, an inhibitor of oxidative phosphorylation (OXPHOS) that primes mitochondria for BCL2 dependence and induces pyroptotic cell death via AMPK signaling and the unfolded protein response. Dr Villaume highlights that EB2023 targets the last ...
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