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How Rabies Makes You Afraid Of Water -- Why It's Such A Dangerous Infection... Rabies, also formally known as hydrophobia, is a viral disease that affects the central nervous system of mammals, including humans. It is transmitted primarily through the bite of an infected animal, such as a dog or bat. The virus infects the brain and spinal cord, leading to severe symptoms like fever, confusion, excessive salivation, difficulty swallowing, and fear of water (which is why it's sometimes referred to