Complement activation in biology
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✨Complement Coagulation Pathway✨ 🔸Interconnection between two major plasma cascade systems in the body: the Complement system (innate immunity) and the Coagulation system (blood clotting). 💐Complement Pathway💐 3 activation routes, all converging at the formation of C3 convertase → C5 convertase → Membrane Attack Complex (MAC, C5b–9): 🔸1.Classical pathway → triggered by Ag–Ab complexes (IgG, IgM) 🔸2.Lectin pathway → triggered by Mannose-binding lectin (MBL) 🔸3.Alternative pathway → triggere
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The complement system doesn't generate compliments for you... but it does help destroy pathogens in your body! Learn all about it in today's #ClinicalCuts. The complement system refers to a group of plasma proteins called the complement proteins, which are produced in the liver, and act collectively to help destroy pathogens. Think of them like a little militia that “complement” the work of antibodies. There are actually three complement pathways: • The classical pathway: called that because it
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