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"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade
3:58
YouTubeElvire Thouvenot
"What is Apoptosis?" The Apoptotic Pathways and the Caspase Cascade
This 3D medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. We start off by taking a look at the important role apoptosis plays in growth and development as well as removing DNA damaged cells. Then we see how activation of the caspase cascade occurs in each external and internal signalling pathway ...
905.7K viewsOct 18, 2016
Caspases Activation
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Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
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Consider the following schematic of a signal transduction pathway that results in apoptosis (Programmed Cell Death).Based on the signaling pathway shown in the schematic, what would be the effect of TNF on the cells that show LOSS OF FUNCTION mutation of the following proteins? Note: Your answer can be "increase cell death" or "decrease cell death".TNFR: Bcl2: Caspases:TNETNER M (Inactive) Cell membrane(Active)JNIMitochondrionCytosolBcl2Cytochrome C releasedNucleus DNA damagecaspasescell deathFi
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