The prevalence of diabetes is increasing and expected to become a major global health burden. Various pharmaceutical approaches have been used to manage diabetes and reduce the associated risks.

We report evidence of a likely low-altitude cosmic airburst near Perkins, Louisiana, associated with semi-consolidated deposits containing abundant shocked quartz grains, a classical impact indicator, ...

Asthma and CVDs are globally prevalent conditions with well-established epidemiological links. Type 2 inflammation, characterized by dominant T H 2 cell responses, eosinophil activation, and ...

We present evidence that Tall el-Hammam, a fortified Middle Bronze Age city in the Jordan Valley, was destroyed by an extraordinary high-energy event in approximately 1650 BCE. Excavations reveal that ...

Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review ...

Methods: Second-generation Nectin4-targeted VHH-CAR-T cells were constructed and the specific killing efficacy was determined against BLCA cells in vitro. VHH Nectin4-CAR lentivirus was transduced ...

Silver nanoclusters (AgNCs) have emerged as highly adaptable nanomaterials with vast potential in theranostic applications, by integrating therapeutic and diagnostic capabilities within a single ...

Objective: The goal of this study was to examine the prognostic performance of optical flow ratio (OFR) among patients with coronary artery disease (CAD) after percutaneous coronary intervention (PCI) ...

In the field of education, inclusion is the process of integrating students with disabilities into mainstream classrooms, thereby guaranteeing that they have equal opportunities to learn and ...

Phosphodiesterase-4 (PDE4), a member of the phosphodiesterase superfamily, has highly important roles in cyclic nucleotide signaling pathways and a variety of skin disorders. Blocking PDE4 activity ...

Abstract Therapy for atrial fibrillation has markedly evolved over the past two decades. Advancements in technology and growing therapeutic options have led to reexamination of the current evidence.

Radiation-induced cardiomyopathy has become a significant clinical challenge with the increased use of thoracic radiation therapy. Recent technological advancements in radiation therapy, such as 3D ...