Liver fibrosis is characterized by the excessive deposition of extracellular matrix, a process primarily driven by activated hepatic stellate cells ...

The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the ...

This important study advances a new computational approach to measure and visualize gene expression specificity across different tissues and cell types. The framework is potentially helpful for ...

A research team has discovered a new mechanism and drug combination strategy that can effectively treat osteoporosis, a ...

In the gut mucosa of IgAN patients, expanded IgA + plasma cells highly express BCMA, supported by APRIL signals, leading to excess pathogenic IgA and kidney injury. Therapeutic depletion of these BCMA ...

Over the past decade, NGS technology has transformed the way to study and explore genomics, epigenomics, and transcriptomics. Improvements in throughput, and accuracy now allow researchers to move ...

Baoshan University College of Resources and Environment, Baoshan University, Baoshan 678000, China Baoshan Key Laboratory of Biodiversity Conservation and Utilization of Gaoligong Mountain, Baoshan ...

While endothelial cells (ECs) are pivotal in vascular development, the chromatin dynamics governing human EC specification remain elusive due to limited access to embryonic models. Here, we ...

This is a new hybrid online course developed by methods and statistics experts in Cochrane. Designed for healthcare professionals, researchers, policy makers, and guideline developers, the course ...

Background: Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with progressive atrial remodeling. Although clinical interventions often target the left atrium, ...

Background: Hypertension is a leading risk factor for cardiovascular disease and is highly prevalent in Asian populations. However, most genome-wide association studies (GWASs) and transcriptome-wide ...