Amyloid transthyretin cardiomyopathy (ATTR-CM) is a progressive and life-threatening heart disease that can lead to increased ventricular wall thickness, restrictive cardiomyopathy, and heart failure.

Givinostat is a ­­pan-HDAC inhibitor. HDACs are stress-response enzymes. 3,5 Patients with DMD are in a chronic stress state and have an overexpression of these enzymes. 6,9 Givinostat inhibits these ...

Diffuse large B-cell lymphoma (DLBCL) is a type of cancer that originates in and affects the lymphatic system. 1 It is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately ...

Researchers from Brazil developed a new clinical score to estimate the probability of neuromyelitis optica spectrum disorder (NMOSD) in patients presenting with optic neuritis. The easily accessible ...

A case of acute lymphoblastic leukemia (ALL) complicated by bullous pemphigoid (BP) presented significant diagnostic and therapeutic challenges, emphasizing the need for prompt identification and ...

Prophylactic use of trimethoprim-sulfamethoxazole (TMP-SMX) may reduce the risk of serious infections in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), ...

The levels of bilirubin and alkaline phosphatase, as well as composites including these 2, can be good surrogate markers of long-term clinical outcomes in primary biliary cholangitis (PBC) in ...

Clinically relevant concentrations of deoxycytidine (dC) and deoxythymidine (dT) are unlikely to cause or be subject to pharmacokinetic drug-drug interactions, according to a new study published in ...

Unsupervised time-frequency analysis of electroencephalography (EEG) recorded from patients with Lennox-Gastaut syndrome (LGS) revealed novel candidate biomarkers that may be useful for the detection ...

A boy who presented for dental treatment experienced periorbital and facial swelling that was eventually diagnosed as hereditary angioedema (HAE). This case report was published in the International ...

Just over half of intrahepatic cholangiocarcinoma (iCCA) specimens in a North American cohort could be classified into small duct and large duct subtypes using morphology alone, according to study ...

Next-generation sequencing (NGS) identified 14 gene mutations with diagnostic and prognostic potential in patients with myelofibrosis (MF), according to a recently published study in the Journal of ...