A 19-year-old woman with a history of depression and anxiety symptoms was admitted to the hospital because of seizure, ...

This Double Take video explores the link between certain strains of human papillomavirus and cancer and reviews the evidence ...

Understanding today’s corporatization of U.S. health care requires seeing it from a historical perspective, as a process that began with a change in the business model of care delivery in the 1920s.

Artificial intelligence could revolutionize health and health care in low- and middle-income countries by addressing the large knowledge and judgment gaps that make care delivery poor. But for AI t ...

Homozygosity for the PNPLA3 risk allele is linked to liver fat accumulation. In phase 1 trials, JNJ-75220795, a hepatocyte-targeted GalNAc-conjugated PNPLA3 siRNA, reduced liver fat in PNPLA3 ...

Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonrandomized studies are often ...

Maintaining medicine’s commitment to excellence while remedying our failures requires distinguishing unnecessary trainee harms from necessary discomforts. Why is it so hard to make these ...

To the Editor: Satizabal et al. (Feb. 11 issue)1 report a steady decline in the incidence of dementia during the past three decades, represented by 5-year epochs, among participants in the Framingh ...

Explore this issue of The New England Journal of Medicine (Vol. 386 No. 7).

The authors describe the implications of the Affordable Care Act for safety-net health systems and how hospital-based safety-net care systems are responding to health care reform.

Leading cardiologists discuss PARADIGM-HF, a trial of angiotensinneprilysin inhibition versus enalapril in advanced heart failure.