eLife3d
Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding
This important work substantially advances our understanding of episodic memory by proposing a biologically plausible mechanism through which hippocampal barcode activity enables efficient memory ...
eLife2d
Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins
Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether ...
eLife2d
Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat
Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain. If CGRP neurons ...
eLife1d
Media Coverage: December roundup of eLife papers in the news
High-profile news coverage that eLife papers generated in December 2024, including Asia Research News, The New York Times and La Gaceta.
eLife3d
Oversized cells activate global proteasome-mediated protein degradation to maintain cell size homeostasis
Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. Previously, we showed that cell size control involves both cell ...
eLife3d
Emergence of Dip2-mediated Specific DAG-based PKC Signalling Axis in Eukaryotes
This is a useful study that adds new data to how different DAG pools influence cellular signaling, and dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from ...
eLife5d
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome
This study addresses fundamental questions surrounding otitis media effusion in Down syndrome, identifying DYRK1A as a key gene involved in the condition. The findings are compelling, highlighting ...
eLife2d
A new pipeline SPICE identifies novel JUN-IKZF1 composite elements
Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between ...
eLife4d
Parasite ‘matchmakers’ genetically alter plant cells to attract insects
Researchers have revealed how parasitic phytoplasmas manipulate plant biology to act as matchmakers, boosting male insect appeal by modulating hosts to attract more reproductive females.
eLife4d
Ancient Trans-Species Polymorphism at the Major Histocompatibility Complex in Primates
This important manuscript presents a thorough analysis of trans-specific polymorphism (TSP) in Major Histocompatibility Complex gene families across primates. The analysis makes the most of currently ...
eLife6d
Prophage regulation of Shewanella fidelis 3313 motility and biofilm formation: implications for gut colonization dynamics in Ciona robusta
Dept Pediatrics, Morsani College of Medicine, University of South Florida, Tampa FL, United States ...
eLife4d
Gene discovery sheds light on common ear condition in people with Down syndrome
The gene DYRK1A could be a potential therapeutic target to treat ‘glue ear’ in people with Down syndrome, according to a new study.