This Epic Chest can only be reached after you consume some Pomegranate. At a random point after doing so, your next attempt to Fast Travel will send you here. Once you've opened the chest, turn around ...

This Chest is guarded by two Harpies, two Swordsmen and two Shieldmen. As noted above, this puzzle requires Heavy Lifting, as the lasers make it impossible to simply push the Heavy Metal Blocks around ...