Proteolysis-targeting chimeras (PROTACs), particularly those incorporating the von Hippel–Lindau (VHL) E3 ligase ligand, present significant physicochemical challenges due to their large molecular ...
T cell exhaustion is a major barrier to antitumor immunity and limits the success of immunotherapies. We show that binding of thrombospondin-1 (TSP-1) to CD47 on CD8 + T cells promotes exhaustion ...
Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, ...
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