New open-source Python-based software boosts space-weather modeling

University of Birmingham experts have created open-source computer software that helps scientists understand how fast-moving ...
eLife

The Locomoting State Selectively Amplifies Activity of Sensitizing Neurons in Primary Visual Cortex

This manuscript presents a valuable analysis of how locomotion modulates the activity of different subtypes of cortical neurons in the mouse primary visual cortex, showing that locomotion more ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...
AHA/ASA Journals

Targeting Interleukin-8–Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome

BACKGROUND: Genetic variants in components or regulators of the RAS-MAPK signaling pathway are causative for severe and early-onset hypertrophic cardiomyopathy (HCM) in patients with Noonan syndrome ...
Fred Hutch

Vulvar Cancer Screening and Diagnosis

Screening tests check for a condition, like cancer, in people who don’t have any signs or symptoms. There aren’t any screening tests for vulvar cancer. The best ways to detect this disease as early as ...
Frontiers

Computational Frameworks for Decision-Making: From Bayesian Inference to Reinforcement Learning Models

The ability to make adaptive decisions in uncertain environments is a fundamental characteristic of biological intelligence. Historically, computational ...