Targeted Oncology

Choosing Wisely in CLL: A Deep Dive Into Frontline Treatment

Explore 2026 CLL frontline choices, from all-oral acalabrutinib–venetoclax to MRD-guided care, plus pipeline advances and ...
IEEE

Learning-Assisted Search Path Reconstruction Empowers Evolution Algorithm for Optimization

Abstract: Evolutionary algorithms serve as a pivotal tool in addressing closed box problems, finding widespread applications across diverse academic disciplines and engineering domains. Despite their ...
PNAS

PD-1 expression identifies proliferating malignant CLL B cells and is a potential biomarker of response to BTK inhibitor therapy

Contributed by Rafi Ahmed; received December 23, 2024; accepted August 2, 2025; reviewed by Carl H. June and Alan J. Korman Patients with CLL often have an abnormal T compartment, with an inverted CD4 ...
IEEE

Accelerated Zeroth-Order Algorithm for Stochastic Distributed Non-Convex Optimization

Abstract: This paper investigates how to accelerate the convergence of distributed optimization algorithms on non-convex problems with only zeroth-order information available. We propose a ...
thorax.bmj

Air pollution associated with incidence and progression trajectory of chronic lung diseases: a population-based cohort study

Correspondence to Dr Hualiang Lin, Department of Epidemiology, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China; linhualiang{at}mail.sysu.edu.cn; Professor Yunfeng Zou, ...
thorax.bmj

Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data

Risks for cardiovascular diseases (CVDs) other than myocardial infarction and stroke in the general COPD population are not well quantified. We used a matched cohort study design and Cox regression to ...