Frenchman has ever defeated a Top 4 seed at a major.
The world No.7 will enter the fourth round under an injury cloud, having required medical attention after just three games.
The 38-year-old served out the American, 3-6, 7-5, 7-6 (1), 6-4, to beat a Top 4 seed for the first time in his 65th Grand Slam appearance.
Alex de Minaur is bidding to equal a career-best result at the Australian Open in his third round match versus Francisco ...