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For a monovalent species, a simple calculation that does not assume partitioning of the ionized species in the oil phase can provide an accurate estimate of the distribution coefficient. Get the ...
BMC Clin Pharmacol. 2010;10:1-27. It is assumed that the tissue consists of N capillaries/cm 3, all with exactly the same geometry, blood flow, permeability, etc. It is also assumed that the relation ...
Masuda, A., and Matsui, Y., INSJ-53, Inst. Nucl. Study, Univ. Tokyo (1963). Masuda, A., and Matsui, Y., Geochim. Cosmochim. Acta (in the press).