You can subtract multiple cells from one cell in Excel by using Minus sign, SUM function and Paste Special feature. Here is a tutorial on this.

Subtracting isn’t as straightforward in Excel as it seems, simply because there’s no actual command to subtract numbers. Instead, you have to use a formula with the subtraction operator.

How to Add the Difference Range In Excel. The simplest way to add cells in Microsoft Excel is using the plus operator, such as "=A1+A2," but that method fails when adding different ranges. Ranges ...