This is a preview. Log in through your library . Abstract The sulfate and glucuronide conjugation of acetaminophen (APAP) by hepatocytes cultured on Matrigel or type 1 collagen was compared to APAP ...

Oncotarget published "Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer" which reported that Glucuronidation controls ...

Figure 1: Ribavirin resistance in patients and cell lines. To determine the clinical relevance of these observations, we examined UGT1A protein levels during response and relapse using confocal ...

Phase I evaluation of troxacitabine administered by continuous infusion in patients with refractory solid tumors No significant financial relationships to disclose. This is an ASCO Meeting Abstract ...

Acyl glucuronides represent a crucial class of metabolites generated through the glucuronidation of carboxylic acid-containing compounds. In the realm of drug metabolism, these conjugates are formed ...

Environmental Health Perspectives, Vol. 105, Supplement 4 (Jun., 1997), pp. 739-747 (9 pages) Glucuronidation and sulfation are phase 2 metabolic reactions catalyzed by large families of different ...

Life-threatening opioid intoxication developed in a patient after he was given small doses of codeine for the treatment of a cough associated with bilateral pneumonia. Codeine is bioactivated by ...

There is a growing list of medications known to adversely affect thyroid function or interpretation of the results of standard thyroid laboratory testing. Many of these drugs are commonly used ...