Optical control of G protein-coupled receptor (GPCR) signaling is a highly valuable approach for comprehensive understanding of GPCR-based physiologies and controlling them precisely. However, ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

Septerna's Native Complex platform isolates GPCRs in their native form, enabling advanced drug discovery for previously undruggable targets, including oral small-molecule therapeutics. Lead molecule ...

GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

If future studies confirm the rescued receptors work normally, the study offers a new roadmap for rare disease drug development.

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new ...

A study published in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single ...

A group of researchers has identified the cause of a 'short-circuit' in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases and could lead to development ...