The researchers captured eight unique structural models and 16 cryogenic electron microscopy maps of the receptor with both ...
15don MSN
A path to safer painkillers – revealed by freezing opioids and their protein receptors in motion
In a first, scientists used cryo-electron microscopy to visualize how opioids and the antidote naloxone (Narcan) engage the mu-opioid receptor, offering insight that could lead to better pain ...
Listening to a favorite song can trigger a profound emotional response that rivals the feelings produced by biological ...
Fentanyl, a mu-opioid receptor agonist, is one of the most commonly used analgesics in hospitals, and may induce long-lasting behavioral and somatosensory impairment in rodents. However, whether the ...
Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Disclaimer: AAAS and EurekAlert! are ...
Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.
Distinct brain circuits drive two key components of addiction to the synthetic opioid drug fentanyl, according to a new finding published in Nature (2024, DOI: 10.1038/s41586-024-07440-x). The ...
University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...
Drug overdose deaths from opioids continue to rise in the U.S. due to the misuse of prescription opioids and the illicit drug market. But an interesting trend has developed: Opioid emergency room ...
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