T cell, Nobel Prize and immune system
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The Nobel Prize in Medicine was awarded to three scientists for discovering how a particular kind of cell can stop the body's immune system from attacking itself.
Regulatory T cells, which help to dampen inflammation, are being used in clinical trials against ailments such as rheumatoid arthritis.
Ohio State researchers have discovered that exhausted T cells collapse under the weight of misfolded proteins, activating a destructive stress response called TexPSR. Unlike normal stress systems, TexPSR accelerates protein production,
Immune cells called double negative T cells are abundant in the intestine but have been poorly understood till date. In a recent study, researchers from Institute of Science Tokyo report that these cells actually have an indispensable role in suppressing intestinal inflammation.
CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.