Science Daily

Research reveals structure of a human endogenous reverse transcriptase

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and ...
Nature

Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase

Figure 1: Three-dimensional structure of the TEN domain. The TEN domain has a mixed αβ structure made up of a core β-sheet, consisting of four short antiparallel β-strands, surrounded by seven ...
JSTOR Daily

Structure of HIV-1 Reverse Transcriptase Bound to an Inhibitor Active against Mutant Reverse Transcriptases Resistant to Other Nonnucleoside Inhibitors

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 29 (Jul. 20, 2004), pp. 10548-10553 (6 pages) We have determined the crystal structure of the HIV type 1 ...
Business Wire

ROME Therapeutics Announces Publication of First Crystal Structure of a Human Endogenous Reverse Transcriptase in PNAS

CAMBRIDGE, Mass.--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome for drug development, today announced a new publication in The Proceedings of the ...
health.economictimes.indiatimes

Scientists explain structure of human endogenous reverse transcriptase

New Jersey : According to a study co-authored by a Rutgers researcher, the crystal structure of a human endogenous reverse transcriptase is comparable to HIV reverse transcriptase, a well-known ...
JSTOR Daily

A Universal Telomerase RNA Core Structure Includes Structured Motifs Required for Binding the Telomerase Reverse Transcriptase Protein

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 41 (Oct. 12, 2004), pp. 14713-14718 (6 pages) Telomerase synthesizes telomeric DNA by copying a short ...
PharmiWeb

ROME Publishes Landmark Nature Paper Revealing First High-Resolution Structure of LINE-1 Reverse Transcriptase (RT) for Drug Discovery

BOSTON--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome to develop breakthrough medicines for serious diseases, today announced a landmark ...