Cognitive tasks, such as learning and memory, require rapid changes to proteins at synapses, such as protein synthesis, degradation, and trafficking. How protein post-translational modifications ...

A study maps how toxic tau disrupts synapses over time, showing early postsynaptic damage that later spreads presynaptically.

The human brain is known to store various memories for long periods of time, progressively learning from new experiences and forming adaptive representations that ultimately guide decision-making and ...

Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

As animals experience new things, the connections between neurons, called synapses, strengthen or weaken in response to events and the activity they cause in the brain. Neuroscientists believe that ...

Scientists disclose how mitochondria control tissue rejuvenation and synaptic plasticity in the adult mouse brain. Nerve cells (neurons) are amongst the most complex cell types in our body. They ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...

A holistic inquiry into how toxic tau impacts synapses provides a new take on the processes that lead to neuronal dysfunction ...

Researchers are testing a new approach to repair early memory loss by protecting brain connections affected in Alzheimer’s ...

By adding, removing, strengthening, or weakening synaptic contacts, our brain encodes new events or forgets previous ones. In AD, synaptic plasticity, the brain's ability to regulate the strength of ...