Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis Colts face the San Francisco 49ers.

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats and more for Colts-49ers.

San Francisco 49ers head coach Kyle Shanahan had strong praise for quarterback Brock Purdy after Monday night's 48-27 win over the Indianapolis Colts.

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game. The 49ers quarterback powered San Francisco to a 48-27 road victory with a career-high five passing touchdowns.

Jonathan Taylor and the Indianapolis Colts came up short on Monday night, suffering defeat against a red-hot San Francisco 49ers side. The Colts put up a respectable fight, but they just couldn’t compete with the Niners, who have now stacked up five straight victories.

Something Purdy had in common with 44-year-old Philip Rivers on Monday — mental sharpness, which came in handy in a big Monday night win.

Bruised, battered yet bouncing back, the 49ers did more than beat the Colts - they improved their shot at winning the division and the NFC's No. 1 seed in the playoffs.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.