This Viral RNA Structure Could Lead to a Universal Antiviral Drug

Researchers identify a shared RNA-protein interaction that could lead to broad-spectrum antiviral treatments for enteroviruses ...
Kaleido Scope

Project 4

The overall goal of this project is to identify new therapies that target influenza virus replication. The global health burden of annual influenza epidemics coupled with the emergence of highly ...
EurekAlert!

Thermostable T7 RNA polymerase enables cleaner, higher-quality therapeutic mRNA production

Building on its success against COVID-19, mRNA technology holds promise for novel vaccines and treatments targeting various diseases. However, a critical challenge remains: current in vitro ...
Business Wire

TriLink BioTechnologies® & Alphazyme Collaborate to Launch New CleanScribe™ RNA Polymerase

SAN DIEGO--(BUSINESS WIRE)--TriLink BioTechnologies and Alphazyme, both part of Maravai LifeSciences, have collaborated to launch CleanScribe™ RNA Polymerase, a novel enzyme that reduces ...
Medscape

Innate Immune Evasion Strategies of Influenza Viruses

For each protein, its corresponding RNA genomic segment is indicated, as well as its approximate molecular weight (in kDa). *Compounds identified with antiviral activity in experimental trials. ‡ US ...
eLife

Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...