Maturation of pre-mRNA by capping, splicing, and cleavage and polyadenylation can occur co-transcriptionally at the gene; the substrate for these reactions is therefore a growing nascent RNA chain.

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

This is a preview. Log in through your library . Abstract Trypanosomes are unique eukaryotic cells, in that they virtually lack mechanisms to control gene expression at the transcriptional level.

In a paper published on aBIOTECH, so far, the authors have for the first time comprehensively analyzed the ...

Recent research on Arabidopsis thaliana flowering may sow the seed of new connections between plant and human reproduction. Gordon Simpson and Caroline Dean at the John Innes Center in Norwich, UK, ...

The Lai lab uses an integrated approach to study selected topics in mRNA processing and modification, including alternative polyadenylation, circularization and RNA methylation. As a core member of ...

The herpes simplex virus (HSV) infected cell culture polypeptide 27 (ICP27) protein is essential for virus infection of cells. Recent studies suggested that ICP27 inhibits splicing in a gene-specific ...

Production of mature RNAs requires many coordinated steps 1,2,3. The m7G cap is a crucial element that is present on RNA polymerase II (Pol-II) transcripts 4. It is added cotranscriptionally after the ...

Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to ...