Chief among these is accurately and reproducibly mimicking natural post-translational modifications. Identifying and characterizing such modifications impact half-life, quality, cost, and potential ...

One of the main goals of proteomics is to unravel the many modifications important for biological activity. Post-translational modifications (PTMs) extend the range of protein function by attaching it ...

Post-translational modifications (PTMs) play a key role in dynamic cellular processes, regulating gene expression, protein activity, localization, and degradation, as well as protein interaction.

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the Institute of Science Tokyo reveal that a tandem allosteric effect of ...

This case study demonstrates how advanced NMR spectroscopy enables high-resolution structural characterization of exenatide.