Writing in Molecular Therapy Nucleic Acids, researchers hypothesized that using poly(A) tail mimetics to enhance mRNA expression from haploinsufficiency-associated genes could be a disease-modifying ...

Human development starts from the fertilization of a fully matured oocyte. Oocyte maturation, fertilization, and early embryo development before zygotic activation is characterized by the absence of ...

An international team of scientists has uncovered a surprising mechanism for how cells measure the length of messenger RNA (mRNA) tails. Rather than determining their size, cells time their growth ...

Researchers from the Broad Institute and Massachusetts Institute of Technology (MIT) have engineered multi-tailed mRNAs that boost mRNA activity levels in cells by as much as 20x and last 2-3 times ...

ENFINIA IVT Ready DNA offers full-length, high-complexity, high-accuracy linear DNA with a long poly(A) tail, manufactured cell-free and delivered in as few as 10 days, ready for immediate use. MENLO ...