Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP ...

Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP ...

Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E. Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N ...

Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a tiny fraction ...

Physics-based ML framework designs IDPs—biomolecules without fixed structures that underlie key functions and diseases such as Parkinson’s.

Mitochondrial dysfunctions are associated with a variety of pathologies, and the onset and progression of disease are accompanied by alterations in extracellular biochemical and mechanical signals.

Liang-Cui Chu, Jan Niklas Offenborn, Leonie Steinhorst, Xu Na Wu, Lin Xi, Zhi Li, Aurore Jacquot, Laurence Lejay, Jörg Kudla and Waltraud X. Schulze • The collective function of calcineurin B-like ...

Prior to the advent of large sequence datasets, it was assumed that innovation and divergence at the morphological and physiological level would be easily explained at the molecular level. Molecular ...