Figure 1: Structural insights into residues involved in modification-induced nucleosome stability. Figure 2: Potential effects of histone modifications on histone–DNA and histone–histone interactions.

For the first time, researchers have unveiled the three-dimensional structure of an overlapping dinucleosome, a newly discovered chromatin structural unit. This may explain how nucleosome ...

Barcelona, 10 October 2024 - DNA—the molecule that carries the genetic information of all living organisms—is packaged within cells in a complex manner that allows it to function efficiently.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 45 (November 9, 2010), pp. 19254-19259 (6 pages) Histone posttranslational modifications and chromatin ...

In a review published in Current Opinion in Structural Biology on May 12, researchers from the Institute of Biophysics of the Chinese Academy Sciences have reviewed the intricate molecular ...

Basic biology textbooks may need a bit of revising now that biologists have discovered a never-before-noticed component of our basic genetic material. Basic biology textbooks may need a bit of ...

Acetylation of lysine residues in the tail domain of histone H3 is well characterized, but lysine residues in the histone globular domain are also acetylated. Histone modifications in globular domain ...

Linker H1 histones facilitate formation of higher-order chromatin structures and play important roles in various cell functions. Despite several decades of effort, the structural basis of how H1 ...