A new genetic screening method allows researchers to efficiently modulate individual genes across entire tissues and provides new insights into human development. The research, published in eLife, is ...

A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...

Neural tube defects (NTDs) rank as the second most prevalent congenital malformation in humans, impacting the central nervous system development in approximately 1 in every 1,000 live births. Over 300 ...

Anencephaly occurs when an infant is born without parts of their brain and skull. It is a severe congenital anomaly, which means that a baby develops anencephaly in the womb. Anencephaly is a ...