Brock Purdy and Philip Rivers go toe-to-toe in what should be an entertaining tilt at Lucas Oil Stadium this Monday night.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

The 49ers clinched a playoff spot on Sunday without even playing, thanks to the Lions’ loss. The Colts are trying to snap their four-game losing streak, as they try to get back into playoff contention ...

Expert recap and game analysis of the New England Patriots vs. Baltimore Ravens NFL game from December 21, 2025 on ESPN.

Get the best 49ers vs. Colts predictions and odds ahead of Week 16 Monday Night Football on December 22, 2025. Take the Over.

Two potential playoff teams in the AFC face off on Sunday night in Week 16, and Drake Maye is looking to show why he and the ...

The NFL Week 16 Monday Night Football contest has a tasty receiving over and a receiving under. Check out who is responsible ...

NFL refs are getting blasted for their performance at the end of Sunday night's Lions vs. Steelers game. The Steelers topped ...