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49ers, Colts and Monday Night Football

Brock Purdy's career-high five TD passes power 49ers past Philip Rivers' Colts on 'Monday Night Football'

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will be remembered as the Brock Purdy game.

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What channel is 49ers-Colts Monday Night Football tonight on TV? Start time, how to stream live

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Monday Night Football predictions, picks, odds for Colts vs 49ers game

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Brock Purdy throws career high 5 TD passes and leads 49ers to 5th straight win, 48-27 over the Colts

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers ' final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory ove...

NFL · 1h

Top touchdowns | Week 16

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Brock Purdy’s 5 touchdowns lead the 49ers to a blowout win over the Colts

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49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers' season debut at home in 48-27 win

Brock Purdy wasn’t the quarterback everyone was talking about during the game but he was really good, throwing for five touchdowns.

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Brock Purdy's fourth TD pass gives 49ers a 31-17 lead

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Here’s how to watch 49ers vs. Colts for free on Monday Night Football

NFL, 49ers and Colts

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· 26m

NFL Refs Accused Of Showing Bias During 49ers vs. Colts

Week 16 of the NFL season is closing out with a thriller between the San Francisco 49ers and the Indianapolis Colts.

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NFL Playoff Bracket Scenarios 2025-26 Week 17, Latest Standings After 49ers vs. Colts

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NFL playoff picture Week 17 sees Patriots, Jaguars, Chargers, Bills clinch

Niners Wire · 1d

San Francisco 49ers vs. Indianapolis Colts injury report | Week 16 2025

Check out the injury report for the San Francisco 49ers (10-4), which currently has 12 players listed (including Christian McCaffrey), as the 49ers ready for their matchup against the Indianapolis Col...

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NFL Monday Night Football prop bets Week 16 2025: 49ers vs. Colts

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49ers playoff picture: How win over Colts impacts postseason chances

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Week 16 Colts vs. 49ers Game discussion

Philip Rivers is starting at quarterback and somewhere up there Jim Irsay is smiling down on his team.

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Monday Night Football: San Francisco 49ers vs Indianapolis Colts

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Will Ricky Pearsall play tonight, Dec. 22? Indianapolis Colts vs San Francisco 49ers inactives, injury report

Indianapolis Colts go with Philip Rivers again

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· 3h · on MSN

Philip Rivers delivers vintage first half performance for Colts, delighting NFL fans

Indianapolis Colts quarterback Philip Rivers made NFL fans smile on Monday night with a great showing in the first half against the San Francisco 49ers.

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NFL expert picks today against the spread: Indianapolis Colts go with Philip Rivers again

· 14h · on MSN

Inside Philip Rivers' startling NFL comeback

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Philip Rivers took the 49ers to school on Colts opening drive

Clinical, surgical, teach tape: these are just a few words that accurately describe Philip Rivers ’s opening drive in primetime against the San Francisco 49ers.

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Philip Rivers' NFL Comeback Includes Genius Off-Field Move

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Philip Rivers' family, kids get key health insurance benefit from Colts QB's comeback from retirement

Jets 2026 NFL Draft pick update after Colts MNF loss in Week 16

The Jets' own first-round pick is currently slated to be fourth overall, behind the New York Giants, Las Vegas Raiders, and Cleveland Browns. With the Browns and Raiders potentially in the market for a QB, the Jets are in a dangerous spot.

4hon MSN

Philip Rivers highlights, stats tonight for Indianapolis Colts vs San Francisco 49ers tonight: QB has 2 TDs to Alec Pierce

Philip Rivers, the grandfather and former Pro Football Hall of Fame semifinalist, came out of retirement to play for the Indianapolis Colts.

Niners Wire on MSN

49ers rookie RB set to make NFL debut in huge game vs. Colts

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

Buffalo Bills fan discussion: Playoff picture chat with Indianapolis Colts on ‘Monday Night Football’

The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the Indianapolis Colts.

18hon MSN

Week 17 odds: Jaguars big favorites at Colts, 49ers favored over Bears

Week 17 features critical matchups with the NFL playoffs approaching. Here are the odds, spreads and totals for every game.