The research team developed a genetically engineered mouse model carrying a mutation (E3896A) in RyR1, which disrupts its calcium-binding site, effectively disabling CICR while preserving ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Muscle contraction is the tightening, shortening, or lengthening of muscles when you do some activity. It can happen when you hold or pick up something, or when you stretch or exercise with weights.

Space exploration activity has been increasing. In turn, researchers are more interested than ever in uncovering more about how space travel affects human health and the progression of disease.

The team’s research is detailed in an article in the latest issue of Upward, official magazine of the ISS National Lab. Principal investigator Siobhan Malany, associate professor in the College of ...

At one point or another, we’ve all experienced the unexpected, intense pain of a muscle cramp. Muscle cramps, also known as muscle spasms or charley horses, are the involuntary contraction of muscle ...

THE mechanism linking the excitation of the plasma membrane of muscle fibres with the contraction of their myofibrils is a matter of great interest to many physiologists 1–3. The present communication ...