Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron ...

Our remarkable ability to perform complex tasks—such as thinking, observing, and touch—stems from proteins, the tiny nanometer-sized molecules in the body. Despite decades of research, our ...

Cryogenic optical microscopy uncovers multiple conformations of PIEZO1 in cell membranes, offering atomic-scale insights into how cells sense force. The team focused on PIEZO1, a mechanosensitive ion ...

Cell membranes play a crucial role in maintaining the integrity and functionality of cells. However, the mechanisms by which they perform these roles are not yet fully understood. Scientists from the ...

Collaboration between researchers at the University of Geneva, Institut de biologie structurale de Grenoble, and the University of Fribourg has shown how lipids and proteins in cell membranes react in ...

Escherichia coli bacteria imaged by high-speed inline force mapping and fluorescence microscopy. Simultaneous topography and elastic modulus maps show a stiffening of the division site. Light and ...

Lipid membranes are not merely passive barriers; rather, they are dynamic structures that underpin a myriad of cellular functions. The intricate interplay between lipid composition, membrane curvature ...

Fluorescent image of PIEZO1 in native cell membrane (left) and an artistic representation of its conformational states resolved with Ångström precision (right). Our remarkable ability to perform ...

Current optical and electron microscopy imaging techniques are not suited for measuring the dynamic characteristics of living microorganisms at tiny scales due to complex sample preparation methods or ...