The major histocompatibility complex (MHC) is a group of genes that encode proteins on the cell surface that have an important role in immune response. Their main role is in antigen presentation where ...
CD8⁺ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate ...
MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...
In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...
Which came first, MHC class I or MHC class II? For decades, it has been debated which of these two similar classes came first in evolution. Now, Keiichiro Hashimoto and his group at Fujita Health ...
The impact of skeletal muscle and adipose tissue on long-term survival in patients with resectable colorectal cancer. This is an ASCO Meeting Abstract from the 2018 ASCO Annual Meeting I. This ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 20 (Sep. 25, 2001), pp. 11521-11526 (6 pages) In 1986, Kärre and colleagues reported that natural killer ...
Optimization of Voyager V1 (VV1) oncolytic virus systemic delivery in combination with cemiplimab and ipilimumab in patients with melanoma and non–small cell lung cancer (NSCLC). Background: Merkel ...
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