From its perch on the cell surface, low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) somehow manages to nab ligands, bring them to the endosome, drop them off, and return to the cell ...
Patients with severe hypercholesterolemia who are unresponsive to a number of lipid-lowering therapies, including a PCSK9 inhibitor and high-dose statin, can have a significant reduction in ...
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