Until recently, proteins called "histones" have been the Rodney Dangerfields ("I don't get no respect!") of the biochemical world. Histones bind to DNA and wrap the genetic material into "beads on a ...

Occasionally, two research disciplines converge at precisely the right moment and propel each other forward. Such is the case with a screen for growth regulators in acute myeloid leukemia and a small ...

According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes.

Biological complexity cannot simply be defined by the number of genes that an organism possesses. We have learned that more advanced species evolved additional regulatory features that allow for an ...