A research team has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule. The breakthrough reveals how ...

The structure of a large nucleic acid complex formed by the 10–23 DNA enzyme bound to an RNA substrate was determined by X–ray diffraction at 3.0 Å resolution. The 82–nucleotide complex contains two ...

Scientists have determined the structure of NatA, an enzyme complex that modifies one end of most human proteins and is made at elevated levels in numerous forms of cancer. Their findings, they ...

Maturation of Asn-linked oligosaccharides in the eukaryotic secretory pathway requires the trimming of nascent glycan chains to remove all glucose and several mannose residues before extension into ...

The γ-secretase enzyme can cleave more than 150 membrane proteins. These include the amyloid precursor protein, which produces deposits linked to Alzheimer’s disease, and the Notch1 protein, which is ...