A research team has solved the crystal structure for an enzyme that plays a key role in DNA methylation, the process by which methyl groups are added to the DNA molecule. The breakthrough reveals how ...
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Assembly instructions for enzymes: Universal rules can help to design an optimal enzyme from scratch
Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme. First, the interface of both enzyme and ...
Using Eppendorf BioSpectrometer for the determination of enzyme activity and substrate concentration
This article shows how enzymatic activity can be effectively determined by means of the Eppendorf BioSpectrometer. The preliminary measurements were carried out by utilizing the “single λ-continuous” ...
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Glycosylation enzyme selectivity in mouse kidneys shows promise for future disease research
Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection. They are attached to many proteins in the body, ...
Mechanistically, the chemists think that in the presence of the enzyme, there’s a formal hydrogen atom abstraction that is ...
Researchers shed light on the role of inositol phosphate molecules in gene regulatory complexes. New knowledge about the mechanism of specific protein complexes in the body could help in the ...
To be used industrially, enzymes usually need to undergo some surgery before they can become chemical workhorses. It may take a nip here, or a tuck there, to sculpt their active site into a shape that ...
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