Enzyme mechanisms of catalysis play many important roles in the functioning of a healthy body. An enzyme may exist as a multi-subunit complex or it may be associated with a cofactor such as adenosine ...

Conjugation and deconjugation of ubiquitin and ubiquitin-like proteins (Ubls) to cellular proteins are highly regulated processes integral to cellular homeostasis. Most often, the C-termini of these ...

Biological cells invest much of their resources into the production of enzymes, which catalyze the conversion of substrates into products. An international team of bioinformaticians and biophysicists ...

Bacterial styrene oxidase isomerase has been known to science for more than three decades, but its mechanism of action has ...

It is well known in physics and chemistry that equal charges repel each other, while opposite charges attract. It was long assumed that this principle also applies when enzymes -- the biological ...

Iridoids are a widespread and evolutionarily ancient class of plant secondary metabolites belonging to the terpenes. They ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental and translational research. The γ-secretase enzyme is capable of cleaving ...

A new study led by Stephen Withers from the University of British Columbia introduces a technique for engineering much more ...

The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed at the University of British Columbia to help prevent a mismatch and ...