Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

Researchers published a new study, “Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution,” in Cell that they say solves the mystery of what drives the genomic ...

Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for ...

BTK and PLCG2 mutations are prevalent in patients with CLL treated with BTKi, but other resistance mechanisms may exist. BTK/PLCG2 mutational profiles have not yet proven useful in guiding subsequent ...

Many sections of the non-coding region of the human genome play a key role in regulating gene activity. But the relationship between non-coding mutations and cancer risk has been a mystery. New ...

Researchers have developed a new technology called tARC-seq that revealed a genetic mechanism affecting SARS-CoV-2 divergence and enabled the team to calculate SARS-CoV-2's mutation rate. Using ...

Inherited mutations in the gene BRCA2 significantly increase the risk of carriers to breast and ovarian cancers. BRCA2, a crucial player in the body's DNA repair system, aids in repairing damaged DNA.

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer ...

A new, less error-prone approach to sequencing Sars-CoV-2 genomes has revealed key information on factors responsible for the development of new COVID-19 variants. Researchers at Baylor College of ...

The SARS-CoV-2 virus that causes COVID has the unsettling ability of often generating variants of itself. Other viruses also mutate, but as SARS-CoV-2 quickly spread throughout the entire human ...