Background: Double-blind placebo-controlled trials are intended to control for the impact of expectancy on outcomes. Whether they always achieve this is, however, questionable. Methods: Reanalysis of ...

Can peer review be improved by withholding information from referees? There is some evidence to suggest it might be, but the jury is still out, reports Alastair Brown. Peer review is a hallmark of a ...

Riluzole is a glutamate-modulating agent with neuroprotective properties approved for use in amyotrophic lateral sclerosis. The efficacy and safety of riluzole vs placebo as an adjunct to ...

The COVID crisis throws into relief what happens when grief has—quite literally—nowhere to go. The evidence suggests that most people summon strengths that surpass their own expectations. Double-blind ...

The extent to which studies of this type are successful in giving reliable information regarding the efficacy of injection therapy depends on the identification of patients whose symptoms are indeed ...