CRISPR—Clustered Regularly Interspaced Short Palindromic Repeats—is the microbial world’s answer to adaptive immunity. Bacteria don’t generate antibodies when they are invaded by a pathogen and then ...
A new base-editing system that uses RNA aptamers to position DNA modifying enzymes at genome targets is adept in performing point-mutation edits and can enhance the therapeutic potential of genome ...
The technology for CRISPR originated in a bacterial immune defense system. Now, the team of one of the researchers who helped pioneer the CRISPR technology, Dr. Feng Zhang, has identified a new type ...
To many working biologists, DNA-modifying enzymes are tools, not unlike a pair of molecule-sized scissors. To Dr. Barry Stoddard, a professor in the Basic Sciences division at Fred Hutch, these ...
Our microbiomes, the communities of microbes living in and on our bodies, influence everything from our weight to our cancer risk. But many of the mechanisms that link bacteria to our health remain ...
Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within ...
In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research. The human nucleus is ...