Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing the first line of defense against ...

A study identified an accurate approach to measuring disease activity in patients with systemic lupus erythematosus (SLE), which is crucial for clinical management.

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

In this analysis of patients with myeloperoxidase-ANCA-positive AAV, all urinary complement C3 fragment levels were elevated significantly compared with healthy controls (P .01 for all). Specific ...

Crippling the complement cascade in a mouse model of AD leads to more plaques, but less neurodegeneration and better function, according to a new study from Cynthia Lemere and colleagues at Brigham ...

Nipocalimab might lower the concentration of anti-acetylcholine receptor antibodies in people with generalized myasthenia gravis, a study shows. PHOENIX, Arizona—Nipocalimab might lower the ...

C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) are two rare kidney diseases. They’re both driven by activity of the complement system, which is a ...

Biogen has announced a definitive agreement to acquire Apellis Pharmaceuticals for approximately $5.6 billion, a move that would expand its presence in complement-mediated diseases, including ...