Cold weather will persist across Southwest and Central Virginia through the next several days. It will be a bitterly cold start to Tuesday—morning temperatures will range from just below zero to the lower teens.

As extreme cold weather grips large sections of the United States, people still need to work and live their lives. CNN wellness expert Dr. Leana Wen has guidance.

Knoxville will remain at the cusp of freezing or below at least through Saturday, Jan. 31, according to the National Weather Service. The highest temperature Knoxville will see all week is 35 degrees. Lows are very cold — in the single digits and low teens.

Cold temperatures continue all week

On Tuesday at 1:04 a.m. the National Weather Service issued a cold weather advisory valid for Wednesday between midnight and 10 a.m. for Hudson, Essex and Union counties.

The extreme cold warning will be in effect through 9 a.m. Tuesday because temperatures are expected to be in the teens or single digits.

A massive winter storm has dumped sleet, freezing rain and snow across much of the U.S., halting air and road traffic and sending temperatures plunging

Overnight Sunday, the entire Lower 48 states were forecast to have their coldest average low temperature since January 2014.